A pure vehicle theory of the contents of consciousness is not possible. While it is true that hard-wired tacit representations are insufficient as content-vehicles, not all tacit representations are hard-wired. The definition of stability offered for patterns of neural activation is not well-motivated, and too simplistic. We disagree in particular with the assumption that stability within a network is purely intrinsic to that network. Many complex forms of stability within a network are apparent only when interpreted by something external to (...) that network. The requirement for interpretation introduces a necessary functional element into the theory of the contents of consciousness, suggesting that a pure vehicle theory of those contents will not succeed. (shrink)

Through discourse with international groups of physicians, we conducted a cross-cultural analysis of the types of ethical dilemmas physicians face. Qualitative analysis was used to categorise the dilemmas into seven themes, which we compared among the physicians by country of practice. These themes were a-theoretically-driven and grounded heavily within the text. We then subjected the dilemmas to an analysis of moral intensity, which represents an important theoretical perspective of ethical decision making. These constructs represent salient determinants of ethical behaviour and (...) our cross-cultural sample afforded us the opportunity to consider both the pragmatic aspects of culture, as they are perceived by physicians, as well as the theory-driven concept of moral intensity. By examining both culture and moral intensity, we hope to better elucidate the complexities of ethical decision-making determinants among physicians in their daily practice. Doing so may potentially have practical implications for ethics training of medical students and foreign physicians. (shrink)

Originally published in 1954, on behalf of the National Institute of Economic and Social Research, this book presents a general review of British economic statistics in relation to the uses made of them for policy purposes. The text begins with an examination, in general terms, of the ways in which statistics can help in guiding or assessing policy, covering housing, coal, the development areas, agricultural price-fixing, the balance of external payments and the balance of the economy. The problems of statistical (...) application are then separately discussed under the headings of quality, presentation and availability, and organization. A full bibliography and reference table of principal British economic statistics are also included. This book will be of value to anyone with an interest in British economic history and statistics. (shrink)

Perfect Paperbount Trim: 6 X 9 Text throught No halftones, No bleeds Update Print/Year line to read for year 2001, 6th printing.

The recent speculation which I have in view is that which finds its inspiration in the great development of scientific discovery and scientific thought in our day. It would be impossible to range over the whole field. Moreover, the efforts which have been made to frame a comprehensive scheme of thought on the foundation supplied by science are those which are truly characteristic of our time. In recent years, science has been passing beyond the experimental stage, and also beyond the (...) limits which, in former times, made it departmental. The great conception of Evolution, and the intimate linking up of astronomy with chemistry and physics, and of chemistry and physics with physiology and biology, have quite altered our outlook on the universe. The mind of to-day passes from space-time to the electron, and from the electron to the structure of the cell, and from the cell to the living organism, with hardly a jolt. Not that the problems which mark the passage from stage to stage in this series have been solved, far from it; but that the different tages have so much the appearance of closing up into one continuous process that we seem to be approaching a view which will regard the whole as one unbroken development. No wonder that philosophic minds, among students and dreamers speculating on the mystery of the Universe, begin to think that some account of it, based on assured results of science, is becoming possible. (shrink)

This festschrift dedicated to Wilfrid Sellars is divided into two parts. Part I consists of eleven critical studies written expressly for this volume. They explore various aspects of Sellars’ philosophic thought. Part II, entitled "Sellarsiana," consists of Sellars’ autobiographical reflections, a bibliography of his works and a new series of papers by him on the problem of knowledge.

In his work on the Redemption Professor Richard of the Faculty of Theology of Lyons presents us with the mature fruit of many years of study and lecturing. He touches on all the aspects of a very complicated theme with that mastery and security that can come only through long years of study and meditation.

Interdisciplinarity has seemingly become a paradigm for modern and meaningful research. Clearly, the interdisciplinary modus of deliberation enables to unfold relevant but quite different disciplinary perspectives to the reflection of broader scientific questions or societal problems. However, whether the comprehensive results of interdisciplinary reflection prove to be valid or to be acceptable in trans-disciplinary terms depends upon certain preconditions, which have to be fulfilled for securing scientific quality and social trust in advisory contexts. The present book is written by experts (...) and practitioners of interdisciplinary research and policy advice. It analyses topical and methodological approaches towards interdisciplinarity, starting with the current role of scientific research in society. The volume continues with contributions to the issues of knowledge and acting and to trans-disciplinary deliberation. The final conclusions address the scientific system as substantial actor itself as well as the relevant research and education politics. (shrink)

This intervention queries whether subjecting feminist jurisprudence to a methodological transfiguration toward pragrammatology (Derrida, in Smith and Kerrigan 1984) holds liberating potential for f (be it ‘woman’, ‘female’ or ‘feminine’) as both a signifier and a subject to be read with lucidity and nuance in feminist justice claims. I examine feminist jurisprudence’s methodological challenges in the settler colonial context of Alaska with respect to the murders of Della Brown (in 2000) and Mindy Schloss (in 2007). I advance my case for (...) pragrammatology as a critical methodology for feminist jurisprudence by subjecting the case(s) of Brown and Schloss to a more lucid (re)reading in two related and intersecting moves. First, I trace and deconstruct the citations of Brown and Schloss’ legal narratives to expose violence in the systemisation of f as a power and legal relation (Ahmed in Soc Legal Stud 4:55–73, 1995). I then examine the paradoxical nature of f justice claims which necessitate a pragrammatological approach. I conclude by advancing counsel on how we might move within paradox. (shrink)

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

How are we to reconcile the existence of a good and omnipotent God with the existence of suffering? The simplest solution is to see all suffering as chastisement for sin. But this solution comes up against the difficulty that the good sometimes suffer and the impious sometimes prosper. ….

In lieu of an abstract, here is a brief excerpt of the content:64. ON HUME'S IS-OUGHT THESIS The famous thesis of Hume about "is" and "ought" I take to be, as I believe it has generally been taken to be: (1) For any factual statement e and any ethical statement h, h is not deducible from e. My object in these brief notes is neither to defend nor to attack (1), but just to point out certain mistakes which have been (...) made, or are apt to be made, about (1), or about what Hume's thesis is. A. Max Black has taken Hume's thesis to be that "only statements of fact can follow- from statements of facti* ¡ a thesis, Black thinks, which Popper and "many other philos c be ; osophers" believe. That is. Black took Hume's thesis to (2)For any factual e and any non-factual h, h is not deducible. from e. It is certain, however, that Popper does not believe (2), and I hope it is untrue that many other philosophers believe it. For (2) is obviously false, and on the contrary, every factual statement has at least one nonfactual consequence; since from any factual statement 'f, the statement *f or not-f, which is not factual, is deducible. But this leaves Hume's thesis (1) untouched, since there is no excuse for confusing it with the foolish thesis (2). B. If a statement h is not deducible from a statement e, then given e, the falsity of h is possible; or in other words, h has less than maximum probability in relation to e. So part at least of the content of Hume's thesis (1) is: (3)For any factual e and ethical h, P(h/e). (shrink)